Loeffler aligned with President Donald Trump in her time in the Senate, touting a "100 percent Trump voting record" during her campaigns.[3][4] After the November 2020 election, Loeffler and Perdue claimed without evidence that there had been unspecified failures in the 2020 U.S. presidential election, and called for the resignation of Georgia secretary of state Brad Raffensperger, who rejected the accusations. She later supported a lawsuit by Trump allies seeking to overturn the election results,[5] and also announced her intention to object to the certification of the Electoral College results in Congress.
Due in part to her stance on the Black Lives Matter movement, and the resulting criticism expressed by many players on the Dream roster and within the league, in February 2021 Loeffler sold her stake in the team.
Loeffler donated portions of her Senate salary to anti-abortion pregnancy centers and an anti-LGBTQ adoption agency.
During the 2024 United States presidential election, Loeffler was a top donor to Donald Trump, having contributed more than $4.9 million to his re-election effort.