What do you think of AdNauseam and their 'poisoning-the-well' approach?

Inspired by the discussion in 'they already have your data' I was reminded that AdNauseam exists. I rarely see it mentioned in privacy circles but the idea seems attractive to me, I've used it before and since it's based on uBlock Origin it was just as effective in adblocking and the "poisoning" itself unobtrusive. How do you guys feel about it? Are there reasons it should be avoided?